The transmission through the reference cavity has deteriorated somewhat since the last touch up alignment last week. Went through the usual signals to see if anything matched up. Nothing from the usual signals. However this time there seems to be coincidence with the horizontal output of the quadrant photodetector in the ISS box. That in turn implies that the pointing out of the pre-modecleaner changed. The change in horizontal seems to coincide with the drive voltage to the pre-modecleaner heater. From the cavity transmission camera, it is obvious that the alignment has drifted in both pitch and yaw.