The first thing I found in the morning was that Beckhoff was dead.
On Windows computer that runs Beckhoff, both of two PLCs showed an error message dialog box ("connection error" or some such) and it was not talking to the hardware.
Alexa did several attempts to make it work without rebooting Windows, but eventually Patrick rebooted Windows.
This did the trick, but it had a side effect of wiping the settings for OPC variables (again).
Bram is working on a sad implementation of burt restore.